Sterols of ketoconazole-inhibited Leishmania mexicana mexicana promastigotes.

  title={Sterols of ketoconazole-inhibited Leishmania mexicana mexicana promastigotes.},
  author={L. John Goad and George G. Holz and David H. Beach},
  journal={Molecular and biochemical parasitology},
  volume={15 3},
Leishmania mexicana mexicana promastigotes grown with cholesterol, supplied in natural products as the free sterol and as cholesteryl esters, were exposed to [2-14C]mevalonate and to the antimycotic drug ketoconazole. Growth was inhibited and cholesterol and 14 alpha-methyl sterols accumulated in free and esterified forms (cholesterol much greater than 4 alpha,14 alpha-dimethylcholesta-8,24-dien-3 beta-ol much greater than 14 alpha-methylcholesta-8,24-dien-3 beta-ol congruent to 14 alpha… CONTINUE READING
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