Sterols of Acanthamoeba culbertsoni strain A-1

@article{Mehdi1988SterolsOA,
  title={Sterols of Acanthamoeba culbertsoni strain A-1},
  author={Haider Mehdi and H. S. Garg and N. K. Garg and Dewan S. Bhakuni},
  journal={Steroids},
  year={1988},
  volume={51},
  pages={551-558}
}
Functional importance for developmental regulation of sterol biosynthesis in Acanthamoeba castellanii.
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TLDR
It is demonstrated that the major sterol of Acanthamoeba castellanii is ergosterol and novel putative precursors and intermediate sterols in its production are identified and provided a putative framework for their further study.
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Evaluated the amebicidal activity of crude extract, hexane, dichloromethane and methanol fractions, and exudate of P. polystachyum against cysts and trophozoites of Acanthamoeba castellanii and results are promising for the discovery of a new therapeutic agent for the amoebic keratitis and suggest the development of new tests.
In vitro evaluation of the amebicidal activity of Pterocaulon polystachyum (Asteraceae) against trophozoites of Acanthamoeba castellanii
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Voriconazole as a first-line treatment against potentially pathogenic Acanthamoeba strains from Peru
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Voriconazole should be established as a first-line treatment against Acanthamoeba infections at least in the studied region of Peru.
Optimized combinations of statins and azoles against Acanthamoeba trophozoites and cysts in vitro
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The combinations of statins together with voriconazole and posaconazole are more efficient than these drugs alone, and these combinations have lower cytotoxicity in mammalian cell lines.
Aminoglucoside/Imidazole in the Treatment of Acanthamoeba Keratitis
  • Medicine
    Journal of Ophthalmology & Clinical Research
  • 2018
TLDR
Five cases of AK with early diagnoses and good response to aminoglucoside/imidazole treatment and achieving acceptable final visual acuity in each case are presented.
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