Sterol-regulatory-element binding protein inhibits upstream stimulatory factor-stimulated hepatic lipase gene expression.

@article{Botma2005SterolregulatoryelementBP,
  title={Sterol-regulatory-element binding protein inhibits upstream stimulatory factor-stimulated hepatic lipase gene expression.},
  author={G J Botma and Diederik van Deursen and Delfina Vieira and Mandy van Hoek and Hans Jansen and Adrie J. M. Verhoeven},
  journal={Atherosclerosis},
  year={2005},
  volume={179 1},
  pages={61-7}
}
Hepatic lipase (HL) not only plays an important role in plasma lipoprotein transport, but may also affect intracellular lipid metabolism. We hypothesize that HL expression is regulated as an integral part of intracellular lipid homeostasis. Addition of oleate (1 mM) to HepG2 cells increased HL secretion to 134+/-14% of control (p<0.02), and increased the transcriptional activity of a 698-bp HL promoter-reporter construct two-fold. Atorvastatin (10 microM) abolished the oleate stimulation. The… CONTINUE READING