Sterol regulatory element-binding protein-2 interacts with hepatocyte nuclear factor-4 to enhance sterol isomerase gene expression in hepatocytes.

@article{Misawa2003SterolRE,
  title={Sterol regulatory element-binding protein-2 interacts with hepatocyte nuclear factor-4 to enhance sterol isomerase gene expression in hepatocytes.},
  author={Koichi Misawa and Taro Horiba and Naoto Arimura and Yuko Hirano and Jun Inoue and Noriaki Emoto and Hitoshi Shimano and Makoto Shimizu and Ryuichiro Sato},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 38},
  pages={36176-82}
}
In the course of an effort to identify unknown targets genes for sterol regulatory element-binding proteins (SREBPs) by PCR, the gene for ATP citrate-lyase was determined to be one such gene. (Sato, R., Okamoto, A., Inoue, J., Miyamoto, W., Sakai, Y., Emoto, N., Shimano, H., and Maeda, M. (2000) J. Biol. Chem. 275, 12497-12502). We here report that gene expression of sterol Delta8-isomerase (SI), which catalyzes the conversion of the 8-ene isomer into the 7-ene isomer in the last steps of the… CONTINUE READING

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SREBP and HNF-4 Regulate SI Gene Expression 36182 by gest on D ecem er 25

  • G. P. Hayhurst, Lee, Y.-H, G. Lambert, J. M. Ward, F. J. Gonzalez
  • Mol. Cell. Biol
  • 2001
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