Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feedback control of cholesterol synthesis and uptake.

@article{Gong2006SterolregulatedUA,
  title={Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feedback control of cholesterol synthesis and uptake.},
  author={Yi Gong and Joon No Lee and Peter Chang-whan Lee and Joseph L Goldstein and Michael Scott Brown and Jin Ye},
  journal={Cell metabolism},
  year={2006},
  volume={3 1},
  pages={15-24}
}
This paper describes a convergent mechanism for the feedback control of cholesterol synthesis and uptake mediated by SREBPs, membrane bound transcription factors. Endoplasmic reticulum (ER) bound SREBPs form complexes with Scap, a polytopic ER protein. In sterol-overloaded cells, Scap/SREBP binds to Insig-1, which retains the complex in the ER. Upon sterol deprivation, the Scap/SREBP complex dissociates from Insig-1, which is then ubiquitinated on lysines 156 and 158 and degraded in proteasomes… CONTINUE READING

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