Sterol-mediated regulation of human lipin 1 gene expression in hepatoblastoma cells.

@article{Ishimoto2009SterolmediatedRO,
  title={Sterol-mediated regulation of human lipin 1 gene expression in hepatoblastoma cells.},
  author={Kenji Ishimoto and Hiroki Nakamura and Keisuke Tachibana and Daisuke Yamasaki and Akemi Ota and Ken-ichi Hirano and Toshiya Tanaka and Takao Hamakubo and Juro Sakai and Tatsuhiko Kodama and Takefumi Doi},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 33},
  pages={22195-205}
}
Lipin 1 plays a crucial role in lipid metabolism in adipose tissue, skeletal muscle, and liver. Its physiological role involves two cellular functions: regulation of phosphatidate phosphatase activity and regulation of fatty acid oxidation. In this study, we have demonstrated that lipin 1 gene (LPIN1) expression is regulated by cellular sterols, which are key regulators of lipid metabolism. We have also characterized the sterol-response element and nuclear factor Y-binding sites in the human… CONTINUE READING