Sterol-dependent nuclear import of ORP1S promotes LXR regulated trans-activation of apoE.

  title={Sterol-dependent nuclear import of ORP1S promotes LXR regulated trans-activation of apoE.},
  author={Sungsoo Lee and Ping-yuan Wang and Yangsik Jeong and David J Mangelsdorf and Richard G. W. Anderson and Peter Michaely},
  journal={Experimental cell research},
  volume={318 16},
Oxysterol binding protein related protein 1S (ORP1S) is a member of a family of sterol transport proteins. Here we present evidence that ORP1S translocates from the cytoplasm to the nucleus in response to sterol binding. The sterols that best promote nuclear import of ORP1S also activate the liver X receptor (LXR) transcription factors and we show that ORP1S binds to LXRs, promotes binding of LXRs to LXR response elements (LXREs) and specifically enhances LXR-dependent transcription via the ME… CONTINUE READING
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Cytoplasmic oxysterol-binding proteins: sterol sensors or transporters?

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