Sterol carrier protein-2 selectively alters lipid composition and cholesterol dynamics of caveolae/lipid raft vs nonraft domains in L-cell fibroblast plasma membranes.

@article{Atshaves2003SterolCP,
  title={Sterol carrier protein-2 selectively alters lipid composition and cholesterol dynamics of caveolae/lipid raft vs nonraft domains in L-cell fibroblast plasma membranes.},
  author={Barbara P. Atshaves and Adalberto M. Gallegos and Avery L McIntosh and Ann B. Kier and Friedhelm Schroeder},
  journal={Biochemistry},
  year={2003},
  volume={42 49},
  pages={14583-98}
}
Although the functional significance of caveolae/lipid rafts in cellular signaling and cholesterol transfer is increasingly recognized, almost nothing is known regarding the lipids, cholesterol dynamics, and factors regulating these properties in caveolae/lipid rafts as opposed to nonlipid raft domains of the plasma membrane. The present findings demonstrate the utility of con-A affinity chromatography for simultaneous isolation of caveolae/lipid raft and nonlipid raft domains from plasma… CONTINUE READING

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