Sterol Biosynthesis Pathway as Target for Anti-trypanosomatid Drugs

  title={Sterol Biosynthesis Pathway as Target for Anti-trypanosomatid Drugs},
  author={Wanderley de Souza and Juliany Cola Fernandes Rodrigues},
  booktitle={Interdisciplinary perspectives on infectious diseases},
Sterols are constituents of the cellular membranes that are essential for their normal structure and function. In mammalian cells, cholesterol is the main sterol found in the various membranes. However, other sterols predominate in eukaryotic microorganisms such as fungi and protozoa. It is now well established that an important metabolic pathway in fungi and in members of the Trypanosomatidae family is one that produces a special class of sterols, including ergosterol, and other 24-methyl… CONTINUE READING


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