Steroids inhibit nicotinic acetylcholine receptors.

  title={Steroids inhibit nicotinic acetylcholine receptors.},
  author={Daniel Bertrand and Soledad Valera and Sonia Bertrand and Marc Ballivet and Duri Rungger},
  volume={2 5},
Application of progesterone to Xenopus oocytes expressing a cloned neuronal nicotinic acetylcholine (nAChR) revealed two effects. The first effect was a fully reversible reduction of the current induced by acetylcholine (ACh), its onset being nearly instantaneous. The second effect, which developed in a few hours, was an irreversible suppression of ACh-evoked currents. The transient inhibition had an apparent Ki of 7 microM when tested with 50 nM ACh, but the percentage of inhibition was… CONTINUE READING

From This Paper

Topics from this paper.
15 Citations
0 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 15 extracted citations

Similar Papers

Loading similar papers…