Steroids and their conjugates in the mammalian brain.

  title={Steroids and their conjugates in the mammalian brain.},
  author={C Mathur and V Venkatesh Prasad and V. Sreenivas Raju and Martin Welch and Seymour Lieberman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={90 1},
Five steroids--3 beta-hydroxypregn-5-en-20-one (pregnenolone; P), 3 beta-hydroxy-5 alpha-pregnan-20-one (3 beta-AP), 3 alpha-hydroxy-5 alpha-pregnan-20-one (3 alpha-AP), 3 beta-hydroxyandrost-5-en-17-one (dehydroepiandrosterone; D), and 3 beta-hydroxy-5 alpha-androstan-17-one (EpiA)--were extracted from the brains of adult male rats, rabbits, and dogs. The steroids exist in this organ as unconjugated compounds and as sulfates, lipoidal esters, and sulfolipids. The techniques for separating… CONTINUE READING