Steroids affect collateral sensitivity to gemcitabine of multidrug-resistant human lung cancer cells.

@article{Bergman2001SteroidsAC,
  title={Steroids affect collateral sensitivity to gemcitabine of multidrug-resistant human lung cancer cells.},
  author={Andries M. Bergman and Herbert M. Pinedo and Godefridus J. Peters},
  journal={European journal of pharmacology},
  year={2001},
  volume={416 1-2},
  pages={19-24}
}
Gemcitabine is phosphorylated by deoxycytidine kinase and thymidine kinase 2 and during S-phase incorporated into DNA. The steroids cortisol and dexamethasone, which regulate cell proliferation and gene expression, are pumped out of the cell by the membrane efflux pumps P-glycoprotein and multidrug resistance-associated protein (MRP), which are blocked by… CONTINUE READING