Steroids, the steroid community, and Upjohn in perspective: a profile of innovation

  title={Steroids, the steroid community, and Upjohn in perspective: a profile of innovation},
  author={John A. Hogg},
  • J. Hogg
  • Published 1 December 1992
  • Biology
  • Steroids

Making British cortisone: Glaxo and the development of corticosteroids in Britain in the 1950s-1960s.

  • V. Quirke
  • Medicine
    Studies in history and philosophy of biological and biomedical sciences
  • 2005

Biotransformation of Cortisone with Rhodococcus rhodnii: Synthesis of New Steroids

Cortisone is a steroid widely used as an anti-inflammatory drug able to suppress the immune system, thus reducing inflammation and attendant pain and swelling at the site of an injury. Due to its

Highly Regioselective and Stereoselective Biohydroxylations of Oxandrolone

Efficient hydroxylations of the steroidal anabolic-androgenic lactone, oxandrolone, in the cultures of three strains of fungi indicate that these strains offer a new way to generate steroidal Hydroxylactones with potential pharmaceutical interest.

Adventures in Rhodococcus - from steroids to explosives.

It is demonstrated that one of these enzymes is involved in the degradation of lignin, one of the most important processes in catabolic processes that have a wide variety of applications.

Biotransformation of cholesterol and 16,17‐alpha epoxypregnenolone by novel Cladosporium sp. strain IS547

An efficient, rapid, and inexpensive biotransformation system for the production of active pharmaceutical intermediates for steroid drugs or intermediates is described.

Special issue—before translational medicine: laboratory clinic relations lost in translation? Cortisone and the treatment of rheumatoid arthritis in Britain, 1950–1960

In exploring cortisone’s first decade in Britain, this article focuses specifically on its role in the treatment of RA and its close analogue ACTH—AdenoCorticoTropic Hormone.

Quest for a Cure: Potential Small-Molecule Treatments for COVID-19, Part 2

  • D. Hughes
  • Medicine
    Organic Process Research & Development
  • 2021
Synthetic work that has been recently published on remdesivir is updated, an overview of several routes to molnupiravir is provided, and classical routes to dexamethasone are reviewed, including some of those more recently developed.



Partial Synthesis of Compounds Related to Adrenal Cortical Hormones. XVI. Preparation of Cortisone and Related Compounds1

In Paper II we (1) have shown that methyl 3(a)-acetoxy-11,12epoxycholanate undergoes fission of the epoxide ring with the introduction of the anionic constituent at C-11. The products of such

Relation between biological activity of hydrocortisone analogues and their rates of inactivation by rat liver enzyme systems.

It is stated that C-20 and δ4-3 ketone Reduction of hydrocortisone, as well as ketone reduction of a number of other steroids, occurs in a combined microsome-supernatant fraction of rat liver.


  • L. SarettA. PatchettS. Steelman
  • Biology, Chemistry
    Fortschritte der Arzneimittelforschung. Progress in drug research. Progres des recherches pharmaceutiques
  • 1963
The present article attempts to summarize the changes in anti-inflammatory potency which attend structural alteration in the hydrocortisone molecule. An effort has been made to include — insofar as

Sterols. C. Diosgenin1

The compound was subjected to reactions applied to sarsasapogenin and other steroidal sapogenins for the removal of the side chain, resulting in derivatives of the pregnane and androstane series.

Microbiological Oxidation of Sterols

The present experiments had a double purpose: (1) to limit the direction of the oxidation as narrowly as possible; (2) to work out a simple reproduction method, for the authors' Azotobacter react with extreme sensitivity to antagonistic bacteria, so that their culture can be made only under the strictest sterile conditions.

Adrenal cortical hormones; analysis by paper partition chromatography and occurrence in the urine of normal persons.

An Electronic Method of Tracing the Movements of Soil-inhabiting Insects and Adrenal Cortical Hormones: Analysis by Paper Partition Chromatography and Occurrence in the Urine of Normal Persons.

Complement Fixation Test in Contagious Ecthyma

The observations clearly indicate that the condition known as contagious ecthyma of the lips, infectious or contagious pustular dermatitis or stomatitis and infectious labial dermatitis has an extensive geographical distribution.