Steroids, the steroid community, and Upjohn in perspective: a profile of innovation

@article{Hogg1992SteroidsTS,
  title={Steroids, the steroid community, and Upjohn in perspective: a profile of innovation},
  author={John A. Hogg},
  journal={Steroids},
  year={1992},
  volume={57},
  pages={593-616}
}
  • J. Hogg
  • Published 1 December 1992
  • Biology
  • Steroids

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It is stated that C-20 and δ4-3 ketone Reduction of hydrocortisone, as well as ketone reduction of a number of other steroids, occurs in a combined microsome-supernatant fraction of rat liver.

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The present article attempts to summarize the changes in anti-inflammatory potency which attend structural alteration in the hydrocortisone molecule. An effort has been made to include — insofar as

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TLDR
The compound was subjected to reactions applied to sarsasapogenin and other steroidal sapogenins for the removal of the side chain, resulting in derivatives of the pregnane and androstane series.

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The observations clearly indicate that the condition known as contagious ecthyma of the lips, infectious or contagious pustular dermatitis or stomatitis and infectious labial dermatitis has an extensive geographical distribution.
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