Steroids, reproductive endocrine function, and affect. A review.

  title={Steroids, reproductive endocrine function, and affect. A review.},
  author={Cheryl Anne Frye},
  journal={Minerva ginecologica},
  volume={61 6},
Although the effects of estrogen (E2) on mood have been studied for some time, there is controversy over the utility of hormone replacement therapy (HRT). Administration of E2 and/or other steroid hormones (e.g., progestogens, androgens, etc.) may be able to reduce increased anxiety and depression that is present with the onset of menopause. However, some studies indicate that E2 replacement does not significantly improve anxiety and/or depressive symptoms in all postmenopausal subjects. More… CONTINUE READING


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