Steroids, neuroactive steroids and neurosteroids in psychopathology
@article{Dubrovsky2005SteroidsNS,
title={Steroids, neuroactive steroids and neurosteroids in psychopathology},
author={Bernardo O. Dubrovsky},
journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
year={2005},
volume={29},
pages={169-192}
}232 Citations
Potential use of neurosteroids and neuroactive steroids as modulators of symptoms of depression, anxiety, and psychotic disorders
- Biology, Medicine
- 2005
It will be profitable to search for and establish symptom‐steroid relationships, as well as pharmacological and endogenous factors that can modulate NS biosynthesis and NAS formation, to be able to use these steroids in therapy.
Neurosteroids, neuroactive steroids, and symptoms of affective disorders
- Psychology, MedicinePharmacology Biochemistry and Behavior
- 2006
Reconsidering Classifi cations of Depression Syndromes: Lessons from Neuroactive Steroids and Evolutionary Sciences
- Biology, Medicine
- 2008
It is proposed that it would be more fruitful to focus on relationships between NAS and symptoms of psychiatric disorders, rather than with typologically defined disorders.
Neuroactive Steroids in Anxiety and Stress
- Biology
- 2007
Ten animal models of anxiety and stress are described that are significantly altered by one or more groups of neuroactive steroids and their interactions with stress-induced behaviors in experimental animals and humans are reviewed.
Neuroactive steroid regulation of neurotransmitter release in the CNS: Action, mechanism and possible significance
- Biology, MedicineProgress in Neurobiology
- 2009
The role of dehydroepiandrosterone (DHEA) in drug-seeking behavior
- Biology, PsychologyNeuroscience & Biobehavioral Reviews
- 2010
3α-reduced neuroactive steroids and their precursors during pregnancy and the postpartum period
- Biology, Medicine
- 2005
Neuroactive steroids increased significantly from 10 to 36 weeks of pregnancy, except for 5β-DHP and PREGNEN which did not change significantly, and at 6 weeks postpartum all steroids were significantly reduced compared with late prenatal values.
Neuro(active)steroids actions at the neuromodulatory sigma1 (σ1) receptor: Biochemical and physiological evidences, consequences in neuroprotection
- BiologyPharmacology Biochemistry and Behavior
- 2006
Neuroactive Steroids and Related Steroids in Autism Spectrum Disorders
- Medicine, Biology
- 2018
Future studies on levels of NASs in ASD should include careful consideration of the factors mentioned above, the possible advantages of saliva sampling and the use of assay procedures that provide simultaneous analysis of levels of a large number of these steroids.
Oxidative Stress-Mediated Brain Dehydroepiandrosterone (DHEA) Formation in Alzheimer’s Disease Diagnosis
- Biology, MedicineFront. Endocrin.
- 2011
The cumulative evidence for oxidative stress as a natural regulator of DHEA formation is presented and the use of this concept to develop a blood-based diagnostic tool for neurodegenerative diseases linked to oxidative stress, such as AD is developed.
References
SHOWING 1-10 OF 344 REFERENCES
The neuropsychopharmacological potential of neuroactive steroids.
- Biology, MedicineJournal of psychiatric research
- 1997
Selective serotonin reuptake inhibitors directly alter activity of neurosteroidogenic enzymes.
- Biology, MedicineProceedings of the National Academy of Sciences of the United States of America
- 1999
The neurosteroid 3alpha-hydroxysteroid-5alpha-pregnan-20-one (allopregnanolone) acts as a positive allosteric modulator of gamma-aminobutyric acid at gamma-aminobutyric acid type A receptors and…
Neuroactive steroids and anxiety disorders.
- BiologyJournal of psychiatry & neuroscience : JPN
- 2002
Diverse mechanisms for rapid steroid effects have now been described, and the nongenomic effects of NASs may involve γ-aminobutyric acid receptors, glutamate receptors, nicotinic acetylcholine receptors, sigma receptors, 5-HT3 receptors, or voltage- or non-voltage-gated calcium channels.
Neuroactive steroids: mechanisms of action and neuropsychopharmacological properties
- Biology, PsychologyPsychoneuroendocrinology
- 2003
Potentiation of GABAergic Neurotransmission by Steroids
- Biology
- 1999
This chapter discusses a few selected areas related to the pharmacology, physiology, and chemistry of GABAergic neuroactive steroids, including their potential roles in alcohol dependence and withdrawal, as well as in affective disorders.
Influence of gender and brain region on neurosteroid modulation of GABA responses in rats.
- BiologyLife sciences
- 1997
GABAA receptor α4 subunit suppression prevents withdrawal properties of an endogenous steroid
- BiologyNature
- 1998
In this model, withdrawal of progesterone leads to increased seizure susceptibility and insensitivity to benzodiazepine sedatives through an effect on gene transcription, which is due to reduced levels of 3α,5α-THP which enhance transcription of the α4 subunit of the GABAA receptor.