Steroids, neuroactive steroids and neurosteroids in psychopathology

@article{Dubrovsky2005SteroidsNS,
  title={Steroids, neuroactive steroids and neurosteroids in psychopathology},
  author={Bernardo O. Dubrovsky},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  year={2005},
  volume={29},
  pages={169-192}
}
  • B. Dubrovsky
  • Published 1 February 2005
  • Biology, Medicine
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry
Potential use of neurosteroids and neuroactive steroids as modulators of symptoms of depression, anxiety, and psychotic disorders
TLDR
It will be profitable to search for and establish symptom‐steroid relationships, as well as pharmacological and endogenous factors that can modulate NS biosynthesis and NAS formation, to be able to use these steroids in therapy.
Neurosteroids, neuroactive steroids, and symptoms of affective disorders
  • B. Dubrovsky
  • Psychology, Medicine
    Pharmacology Biochemistry and Behavior
  • 2006
Reconsidering Classifi cations of Depression Syndromes: Lessons from Neuroactive Steroids and Evolutionary Sciences
TLDR
It is proposed that it would be more fruitful to focus on relationships between NAS and symptoms of psychiatric disorders, rather than with typologically defined disorders.
Neuroactive Steroids in Anxiety and Stress
TLDR
Ten animal models of anxiety and stress are described that are significantly altered by one or more groups of neuroactive steroids and their interactions with stress-induced behaviors in experimental animals and humans are reviewed.
Neuroactive steroid regulation of neurotransmitter release in the CNS: Action, mechanism and possible significance
  • P. Zheng
  • Biology, Medicine
    Progress in Neurobiology
  • 2009
3α-reduced neuroactive steroids and their precursors during pregnancy and the postpartum period
TLDR
Neuroactive steroids increased significantly from 10 to 36 weeks of pregnancy, except for 5β-DHP and PREGNEN which did not change significantly, and at 6 weeks postpartum all steroids were significantly reduced compared with late prenatal values.
Neuroactive Steroids and Related Steroids in Autism Spectrum Disorders
TLDR
Future studies on levels of NASs in ASD should include careful consideration of the factors mentioned above, the possible advantages of saliva sampling and the use of assay procedures that provide simultaneous analysis of levels of a large number of these steroids.
Oxidative Stress-Mediated Brain Dehydroepiandrosterone (DHEA) Formation in Alzheimer’s Disease Diagnosis
TLDR
The cumulative evidence for oxidative stress as a natural regulator of DHEA formation is presented and the use of this concept to develop a blood-based diagnostic tool for neurodegenerative diseases linked to oxidative stress, such as AD is developed.
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