Steroidogenic gene expression during sex determination in the frog Rana rugosa.

@article{Maruo2008SteroidogenicGE,
  title={Steroidogenic gene expression during sex determination in the frog Rana rugosa.},
  author={Koichi Maruo and Mari Suda and Satoshi Yokoyama and Yuki Oshima and Masahisa Nakamura},
  journal={General and comparative endocrinology},
  year={2008},
  volume={158 1},
  pages={
          87-94
        }
}
Rana rugosa is unique among frog species in that it has two distinct types of sex chromosomes in two separate forms (XX/XY and ZZ/ZW). Treatment with sex steroids can reverse its gender from female to male or male to female. This phenomenon makes it a novel model for studying gonadal differentiation. The physiological role of sex steroids in sex differentiation in amphibians is yet unclear, however. To address this issue, we cloned the cDNAs of 17betaHSD types 8 (17betaHSD8) and 12 (17betaHSD12… CONTINUE READING
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