Steroidogenesis in isolated adrenocortical cells during development in rats.

  title={Steroidogenesis in isolated adrenocortical cells during development in rats.},
  author={Maya Arai and Eric P. Widmaier},
  journal={Molecular and cellular endocrinology},
  volume={92 1},
After postnatal day 1 (d1), the hypothalamo-pituitary-adrenal axis of neonatal rats becomes less responsive to certain stimuli for up to 2 weeks. The present study was designed to quantify the development of adrenocortical cell responsiveness to its normal secretagogue, adrenocorticotropic hormone (ACTH), and to better localize intracellular sites of adrenal cell hyporesponsivity. Maximum steroidogenic responses of collagenase-dispersed adrenocortical cells (using two isolation methods) to ACTH… CONTINUE READING


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