Steroidal saponins from the rhizomes of Dioscorea bulbifera and their cytotoxic activity.

@article{Liu2011SteroidalSF,
  title={Steroidal saponins from the rhizomes of Dioscorea bulbifera and their cytotoxic activity.},
  author={Hai Liu and Gui-xin Chou and Jun-ming Wang and Li-Li Ji and Zheng-tao Wang},
  journal={Planta medica},
  year={2011},
  volume={77 8},
  pages={845-8}
}
Two new steroidal saponins, diosbulbisides D (1) and E (2), along with five known saponins (3- 7) were isolated from the rhizomes of Dioscorea bulbifera L. Their structures were elucidated on the basis of spectral data. Compounds 6 and 7, two 3- O-trisaccharides of diosgenin spirostanes, showed moderate cytotoxic activity against human hepatocellular carcinoma cells, with IC₅₀ values of 3.89 µM and 7.47 µM on SMMC7721, and 10.87 µM and 19.10 µM on Bel-7402 cell lines, respectively.