Steroidal Alkaloids from Veratrum nigrum Enhance Glucose Uptake in Skeletal Muscle Cells.

@article{Kang2015SteroidalAF,
  title={Steroidal Alkaloids from Veratrum nigrum Enhance Glucose Uptake in Skeletal Muscle Cells.},
  author={ChuHyun Kang and Joo-Hui Han and Joonseok Oh and Roshan Rajan Kulkarni and Wei Zhou and Daneel Ferreira and Tae Su Jang and Chang-Seon Myung and MinKyun Na},
  journal={Journal of natural products},
  year={2015},
  volume={78 4},
  pages={
          803-10
        }
}
Veratrum nigrum is recognized as a medicinal plant used for the treatment of hypertension, stroke, and excessive phlegm. Chemical investigation of the roots and rhizomes led to the isolation of five new steroidal alkaloids, jervine-3-yl formate (1), veramarine-3-yl formate (2), jerv-5,11-diene-3β,13β-diol (3), (1β,3β,5β)-1,3-dihydroxyjervanin-12(13)-en-11-one (4), and veratramine-3-yl acetate (5). Compounds 1 and 5 exhibited potent inhibitory activity (11.3 and 4.7 μM, respectively) against… CONTINUE READING
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