Steroid-withdrawal at 3 days after renal transplantation with anti-IL-2 receptor alpha therapy: a prospective, randomized, multicenter study.

@article{Meulen2004SteroidwithdrawalA3,
  title={Steroid-withdrawal at 3 days after renal transplantation with anti-IL-2 receptor alpha therapy: a prospective, randomized, multicenter study.},
  author={Cornelis G ter Meulen and Iza C van Riemsdijk and Ronald J. Hen{\'e} and Maarten H. L. Christiaans and George Florimond Borm and Teun van Gelder and Luuk B Hilbrands and Willem W Weimar and Andries J. Hoitsma},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  year={2004},
  volume={4 5},
  pages={803-10}
}
Steroids have been included in most immunosuppressive regimens after renal transplantation, but are feared for their side-effects. We conducted a prospective multicenter study to investigate whether it is feasible to withdraw steroids early after transplantation with the use of anti-IL-2Ralpha induction, tacrolimus and mycophenolate mofetil (MMF). A total of 364 patients were randomized to receive either two doses of daclizumab (1 mg/kg) and, for the first 3 days, 100 mg of prednisolone… CONTINUE READING
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