Steroid treatment, accumulation, and antagonism of P-glycoprotein in multidrug-resistant cells.

@article{Barnes1996SteroidTA,
  title={Steroid treatment, accumulation, and antagonism of P-glycoprotein in multidrug-resistant cells.},
  author={Kevin M. Barnes and Bruce Dickstein and Gordon B. Cutler and Tito Fojo and Susan E Bates},
  journal={Biochemistry},
  year={1996},
  volume={35 15},
  pages={4820-7}
}
According to multiple reports, progesterone is not transported by P-glycoprotein (Pgp), which mediates multidrug resistance through active drug efflux. However, progesterone has been shown to block Pgp- mediated efflux of other drugs. To extend these observations and to examine the effect of modulating Pgp phosphorylation, the accumulation of progesterone… CONTINUE READING