Steroid sulfatase inhibitors.

@article{Nussbaumer2004SteroidSI,
  title={Steroid sulfatase inhibitors.},
  author={Peter Nussbaumer and Andreas Billich},
  journal={Medicinal research reviews},
  year={2004},
  volume={24 4},
  pages={529-76}
}
Steroid sulfatase (STS) regulates the local production of estrogens and androgens from systemic precursors in several tissues. The enzyme catalyzes the hydrolysis of the sulfate esters of 3-hydroxy steroids, which are inactive transport or precursor forms of the active 3-hydroxy steroids. STS inhibitors are expected to block the local production and, consequently, to reduce the local levels of the hormones. Therefore, they are considered as potential new therapeutic agents for the treatment of… CONTINUE READING

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