• Corpus ID: 38101754

Steroid structure and androgenic activity. Specificities involved in the receptor binding and nuclear retention of various androgens.

@article{Liao1973SteroidSA,
  title={Steroid structure and androgenic activity. Specificities involved in the receptor binding and nuclear retention of various androgens.},
  author={Shutsung Liao and Tehming Liang and Senmaw Fang and E Casta{\~n}eda and Tsang C Shao},
  journal={The Journal of biological chemistry},
  year={1973},
  volume={248 17},
  pages={
          6154-62
        }
}
Abstract In rat ventral prostate the action of many natural androgens, including testosterone, appears to depend on their conversion to 5α-dihydrotestosterone that binds firmly to an androgen receptor (β protein) and is subsequently retained by cell nuclei. We have found, however, that many potent synthetic androgens can bind directly to β protein and to prostate cell nuclei without a metabolic conversion. For these studies, simple methods were devised to compare the receptor binding affinities… 
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