Steroid structural requirements for high affinity binding to human sex steroid binding protein (SBP)

@article{Cunningham1981SteroidSR,
  title={Steroid structural requirements for high affinity binding to human sex steroid binding protein (SBP)},
  author={G. Cunningham and D. Tindall and T. Lobl and J. Campbell and A. Means},
  journal={Steroids},
  year={1981},
  volume={38},
  pages={243-262}
}
The sex steroid binding protein (SBP) which binds androgens circulating in the blood of man has been examined to determine the structural requirements for high affinity binding. SBP was purified partially and the ability of each of more than 150 steroids to compete with [3H]dihydrotestosterone (17 beta-hydroxy-5 alpha-androstan-3-one) for binding to SBP was assessed. Binding was enhanced by reduction of the delta 4 double bond to 5 alpha-dihydro, addition of a methyl group at C-4 and in one… Expand
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  • 6
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  • 1988
  • 8
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  • The Journal of Steroid Biochemistry and Molecular Biology
  • 1991
  • 146
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  • 181
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  • 1
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References

SHOWING 1-10 OF 20 REFERENCES
Differences in steroid specificity for rat androgen binding protein and the cytoplasmic receptor
  • 76
Structural Requirements for Steroid Binding to Androgen Binding Proteins
  • 14
Transport of steroid hormones: interaction of 70 drugs with testosterone-binding globulin and corticosteroid-binding globulin in human plasma.
  • 205
An androgen binding protein in the testicular cytosol of human testis. Comparison with human plasma testosterone-estrogen binding globulin.
  • A. Hsu, P. Troen
  • Medicine, Chemistry
  • The Journal of clinical investigation
  • 1978
  • 72
  • PDF
Multiple Forms of Rat Testicular Androgen Binding Protein: Physicochemical Properties and the Effect of Ca++
  • 8
Studies of testosterone binding globulin.
  • T. Kato, R. Horton
  • Chemistry, Medicine
  • The Journal of clinical endocrinology and metabolism
  • 1968
  • 111
Androgen-binding activity in the human testis and epididymis.
  • 19
Influence of purified plasma proteins on testosterone uptake and metabolism by normal and hyperplastic human prostate in "constant-flow organ culture".
  • 28
Studies on the binding of testosterone to human plasma.
  • 241
Androgen Binding Proteins and Androgen Levels in the Human Testis and Epididymis
  • 36
...
1
2
...