Steroid structural requirements for high affinity binding to human sex steroid binding protein (SBP)

@article{Cunningham1981SteroidSR,
  title={Steroid structural requirements for high affinity binding to human sex steroid binding protein (SBP)},
  author={G. Cunningham and D. Tindall and T. Lobl and J. Campbell and A. Means},
  journal={Steroids},
  year={1981},
  volume={38},
  pages={243-262}
}
The sex steroid binding protein (SBP) which binds androgens circulating in the blood of man has been examined to determine the structural requirements for high affinity binding. SBP was purified partially and the ability of each of more than 150 steroids to compete with [3H]dihydrotestosterone (17 beta-hydroxy-5 alpha-androstan-3-one) for binding to SBP was assessed. Binding was enhanced by reduction of the delta 4 double bond to 5 alpha-dihydro, addition of a methyl group at C-4 and in one… Expand
30 Citations
Sex hormone-binding globulin/androgen-binding protein: Steroid-binding and dimerization domains
  • 69
2-Iodoestradiol binds with high affinity to human sex hormone binding globulin (SHBG).
  • 8
Profiles of ligands of sex hormone binding globulin in human serum.
  • B. Murphy
  • Biology, Medicine
  • Journal of steroid biochemistry
  • 1988
  • 8
Steroid interactions with cytochrome P-450 from testis microsomes.
  • 1
The plasma sex steroid binding protein (SBP or SHBG). A critical review of recent developments on the structure, molecular biology and function
  • P. Pétra
  • Biology, Medicine
  • The Journal of Steroid Biochemistry and Molecular Biology
  • 1991
  • 146
Sex hormone-binding globulin is synthesized in target cells.
  • 181
  • PDF
...
1
2
3
...

References

SHOWING 1-10 OF 20 REFERENCES
Studies of testosterone binding globulin.
  • T. Kato, R. Horton
  • Chemistry, Medicine
  • The Journal of clinical endocrinology and metabolism
  • 1968
  • 111
Androgen-binding activity in the human testis and epididymis.
  • 19
Studies on the binding of testosterone to human plasma.
  • 241
...
1
2
...