Steroid secretion in polycystic ovarian disease after ovarian suppression by a long-acting gonadotropin-releasing hormone agonist.

@article{Chang1983SteroidSI,
  title={Steroid secretion in polycystic ovarian disease after ovarian suppression by a long-acting gonadotropin-releasing hormone agonist.},
  author={Russell Jeffrey Chang and L R Laufer and David Roy Meldrum and J L DeFazio and John K H Lu and Wylie W. Vale and Jean E F Rivier and Howard L Judd},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1983},
  volume={56 5},
  pages={897-903}
}
The principal glandular source of increased serum androgens in polycystic ovarian disease (PCO) is controversial), since complete separation of ovarian from adrenal function has not been achieved. The purpose of this study was to determine whether a long-acting GnRH agonist could be used to selectively inhibit ovarian steroid secretion in PCO and ovulatory women. Each of five typical PCO patients and six ovulatory subjects on day 2 of their menstrual cycles received D-Trp6-Pro9-NEt-LHRH (GnRH-a… CONTINUE READING
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