Steroid responsiveness of fibroblasts of paraquat injured lungs.

Abstract

We evaluated the effect of dexamethasone on the synthesis of fibronectin by rat lung fibroblasts. A dose dependent inhibition was observed in fibroblasts isolated from normal lungs and in fibroblasts isolated early (4 days) and late (14 days) after the administration of endobronchial paraquat, and was more pronounced in fibroblasts exposed to dexamethasone… (More)

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