Steroid resistance in asthma: mechanisms and treatment options.

  title={Steroid resistance in asthma: mechanisms and treatment options.},
  author={Ian M. Adcock and Paul M. Ford and Pank Bhavsar and Tehireem Ahmad and Kian Fan Chung},
  journal={Current allergy and asthma reports},
  volume={8 2},
Glucocorticoid insensitivity presents a profound management problem in patients with asthma because conventional therapies are not effective. Glucocorticoids, acting through the glucocorticoid receptor (GR), are able to selectively repress inflammatory gene expression by utilizing several distinct mechanisms targeting nuclear factor-varphiB and activator protein-1 activation complexes and by effects on mitogen-activated protein kinases. Different model systems often activate distinct sets of… CONTINUE READING