Steroid regulation of cell specific secreted phosphoprotein 1 (osteopontin) expression in the pregnant porcine uterus.

@article{White2005SteroidRO,
  title={Steroid regulation of cell specific secreted phosphoprotein 1 (osteopontin) expression in the pregnant porcine uterus.},
  author={Frankie J White and Jason W Ross and Margaret M. Joyce and Rodney D Geisert and Robert C. Burghardt and Gregory A. Johnson},
  journal={Biology of reproduction},
  year={2005},
  volume={73 6},
  pages={1294-301}
}
Secreted phosphoprotein 1 (SPP1, commonly referred to as osteopontin and formerly known as bone sialoprotein 1, early T-lymphocyte activation 1) is an extracellular matrix/adhesion molecule that is upregulated in the pregnant uterus of all mammals examined to date. This study focused on the pig, which has true epitheliochorial placentation and exhibits induction of SPP1 mRNA in luminal epithelium (LE) just before conceptus attachment and in glandular epithelium (GE) after Day 30 of pregnancy… CONTINUE READING

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