Steroid receptor heterodimerization demonstrated in vitro and in vivo.

@article{Liu1995SteroidRH,
  title={Steroid receptor heterodimerization demonstrated in vitro and in vivo.},
  author={Weihong Liu and Jen-Chywan Wang and Nicholas K. Sauter and David Pearce},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1995},
  volume={92 26},
  pages={12480-4}
}
The mineralocorticoid and glucocorticoid receptors (MR and GR, respectively) are members of the intracellular receptor superfamily that bind as homodimers to the same hormone response elements (HREs). Physiological evidence suggests that MR and GR interact with each other in cells that express both receptors, implying that they might directly interact in the regulation of transcription initiation. Indeed, we have found that coexpressed MR and GR interact functionally at the transcriptional… CONTINUE READING