Steroid receptor coactivator SRC-1 exhibits high expression in steroid-sensitive brain areas regulating reproductive behaviors in the quail brain.

@article{Charlier2002SteroidRC,
  title={Steroid receptor coactivator SRC-1 exhibits high expression in steroid-sensitive brain areas regulating reproductive behaviors in the quail brain.},
  author={Thierry D. Charlier and Bernard Lakaye and Gregory F Ball and Jacques Balthazart},
  journal={Neuroendocrinology},
  year={2002},
  volume={76 5},
  pages={297-315}
}
The steroid receptor coactivator SRC-1 modulates ligand-dependent transactivation of several nuclear receptors, including the receptors for sex steroid hormones. Reducing the expression of SRC-1 by injection of specific antisense oligonucleotides markedly inhibits the effects of estrogens of the sexual differentiation of brain and behavior in rats and inhibits the activation of female sexual behavior in adult female rats. SRC-1 thus appears to be involved in both the development and activation… CONTINUE READING

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