Steroid receptor coactivator (SRC)-1 and SRC-3 differentially modulate tissue-specific activation functions of the progesterone receptor.

@article{Han2006SteroidRC,
  title={Steroid receptor coactivator (SRC)-1 and SRC-3 differentially modulate tissue-specific activation functions of the progesterone receptor.},
  author={Sang Jun Han and Francesco J. Demayo and Jianming Xu and Sophia Y. Tsai and Ming-jer Tsai and Bert W O'malley},
  journal={Molecular endocrinology},
  year={2006},
  volume={20 1},
  pages={45-55}
}
The progesterone receptor (PR) and its coactivators and corepressors play an important role in female reproductive function. To investigate the functional interactions between PR and steroid receptor coactivators (SRCs) required for regulation of gene transcription in vivo, we crossed PR activity indicator (PRAI) mice with SRC-1(+/-) and SRC-3(+/-) mice to generate bigenic mice, PRAI-SRC-1(-/-) and PRAI-SRC-3(-/-). In the mammary gland, PR activity in the luminal epithelium of both wild-type… CONTINUE READING
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