Steroid metabolism in the mammalian brain: 5alpha-reduction and aromatization.

  title={Steroid metabolism in the mammalian brain: 5alpha-reduction and aromatization.},
  author={F{\'a}bio Celotti and Paola Negri-Cesi and Angelo Poletti},
  journal={Brain research bulletin},
  volume={44 4},
Several steroid molecules, including androgens, estrogens, progestagens, and corticostereroids, are able to modulate the brain development and functions. These compounds are not always active in their own natural molecular configuration but they often need to be transformed at the level of their target cells into 'active metabolites'. The two major metabolic pathways that transform steroids in the brain are: the 5alpha-reductase-3alpha-hydroxy-steroid dehydrogenase and the aromatase pathways… CONTINUE READING

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