Steroid metabolism gene CYP17 polymorphism and the development of breast cancer.

  title={Steroid metabolism gene CYP17 polymorphism and the development of breast cancer.},
  author={Katja Mitrunen and Nadejda Jourenkova and Vesa V. Kataja and Matti Eskelinen and V. M. Kosma and Simone Benhamou and Harri Vainio and Matti Uusitupa and Ari P Hirvonen},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  volume={9 12},
The potential role of the polymorphism in the CYP17 gene was evaluated in a case-control study with 483 incident breast cancer patients and 482 population controls, all of homogenous Finnish origin. Our data disagree with the earlier suggestions that the minor A2 variant of CYP17 would pose an increased risk for developing advanced breast cancer. In contrast, a tendency of inverse association was found for premenopausal women carrying the A2 allele containing genotypes with a multivariate… CONTINUE READING

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