Steroid hormones and the Luftwaffe. A venture into fundamental strategic research and some of its consequences: The Birch reduction becomes a birth reduction

  title={Steroid hormones and the Luftwaffe. A venture into fundamental strategic research and some of its consequences: The Birch reduction becomes a birth reduction},
  author={A. Birch},
  • A. Birch
  • Published 1992
  • Medicine, Biology
  • Steroids
I recount my involvement in the development of biologically active, totally synthetic steroid hormones since 1941. The reasons for my approach to the first total synthesis of a potent androgen are given. I touch on the even more important general synthetic outcomes from ideas generated by the search for useful amounts of a cortically active hormone, such as novel angular methylations, partial hydrogenations of aromatic systems (Birch reductions), and novel usages in synthesis based on the… Expand
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  • V. Quirke
  • Medicine
  • Studies in history and philosophy of biological and biomedical sciences
  • 2005
The varied and flexible strategy that enabled Glaxo to maintain this head start, and the scientific and technical capabilities which the company subsequently built up, enabling them to dominate the market for corticosteroids in Britain, are described. Expand
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  • S. Kelly, D. Kelly
  • Biology, Medicine
  • Philosophical Transactions of the Royal Society B: Biological Sciences
  • 2013
The first eukaryote genome revealed three yeast cytochromes P450 (CYPs), hence the subsequent realization that some microbial fungal genomes encode these proteins in 1 per cent or more of all genesExpand
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This article investigates the emergence of the concept of stress in the 1930s and outlines its changing disciplinary and conceptual frames up until 1960. Originally stress was a physiological conceptExpand
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Novel insertion, rearrangement and addition products from dibromocarbene and dichlorocarbene reactions with 5(10)-unsaturated steroids have been identified. The dihalogenocarbenes were prepared underExpand
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Authors for correspondence
Steroids: reactions and partial syntheses.
  • V. Černý
  • Chemistry, Medicine
  • Natural product reports
  • 1994


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