Steroid hormone synthetic pathways in prostate cancer

  title={Steroid hormone synthetic pathways in prostate cancer},
  author={Elahe A. Mostaghel},
  booktitle={Translational andrology and urology},
While androgen deprivation therapy (ADT) remains the primary treatment for metastatic prostate cancer (PCa) since the seminal recognition of the disease as androgen-dependent by Huggins and Hodges in 1941, therapy is uniformly marked by progression to castration-resistant prostate cancer (CRPC) over a period of about 18 months, with an ensuing median survival of 1 to 2 years. Importantly, castration does not eliminate androgens from the prostate tumor microenvironment. Castration resistant… CONTINUE READING


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