Steroid hormone stimulation of Na+ transport in A6 cells is mediated via glucocorticoid receptors.

@article{Schmidt1993SteroidHS,
  title={Steroid hormone stimulation of Na+ transport in A6 cells is mediated via glucocorticoid receptors.},
  author={Thomas J{\"u}rgen Schmidt and Russell F. Husted and John B. Stokes},
  journal={The American journal of physiology},
  year={1993},
  volume={264 4 Pt 1},
  pages={C875-84}
}
The A6 cell line derived from the toad kidney forms polarized, highly differentiated epithelial monolayers in culture and has been utilized as an experimental model for studying regulation of transepithelial Na+ transport by aldosterone. In the present study we evaluated the specific role(s) of glucocorticoid and mineralocorticoid receptors in mediating this enhanced electrogenic Na+ transport, which was measured experimentally as an increase in short-circuit current (Isc). Our data demonstrate… CONTINUE READING

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