Steroid hormone profiles in women treated with aminoglutethimide for metastatic carcinoma of the breast.

@article{Samojlik1982SteroidHP,
  title={Steroid hormone profiles in women treated with aminoglutethimide for metastatic carcinoma of the breast.},
  author={Eugeniusz Samojlik and Richard J. Santen and Marvin A. Kirschner and Norman H. Ertel},
  journal={Cancer research},
  year={1982},
  volume={42 8 Suppl},
  pages={3349s-3352s}
}
Recent evidence suggests that aminoglutethimide (AG), a known inhibitor of adrenal steroidogenesis, is a potent blocker of aromatase and thus of estrogen production. These properties of AG have been exploited clinically to reduce the biosynthesis of adrenal estrogen precursors and extraglandular estrogen production in postmenopausal women with metastatic breast carcinoma. In this study, we have explored the effects of AG on a variety of steroids, including delta 5-C19 and -C21 compounds and… CONTINUE READING