Steroid hormone hydroxylase specificities of eleven cDNA-expressed human cytochrome P450s.

@article{Waxman1991SteroidHH,
  title={Steroid hormone hydroxylase specificities of eleven cDNA-expressed human cytochrome P450s.},
  author={D. Waxman and D. Lapenson and T. Aoyama and H. Gelboin and F. Gonzalez and K. Korzekwa},
  journal={Archives of biochemistry and biophysics},
  year={1991},
  volume={290 1},
  pages={
          160-6
        }
}
Steroid hydroxylation specificities were determined for 11 forms of human cytochrome P450, representing four gene families and eight subfamilies, that were synthesized in human hepatoma Hep G2 cells by means of cDNA-directed expression using vaccinia virus. Microsomes isolated from the P450-expressing Hep G2 cells were isolated and then assayed for their regioselectivity of hydroxylation toward testosterone, androstenedione, and progesterone. Four of the eleven P450s exhibited high steroid… Expand
Cytochrome P450 3A9 catalyzes the metabolism of progesterone and other steroid hormones
Inhibition of coumarin 7-hydroxylase activity in human liver microsomes.
Multiple functions of aromatase and the active site structure; aromatase is the placental estrogen 2-hydroxylase
Separate and interactive regulation of cytochrome P450 3A4 by triiodothyronine, dexamethasone, and growth hormone in cultured hepatocytes.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 34 REFERENCES
Constitutive testosterone 6 beta-hydroxylase in rat liver.
...
1
2
3
4
...