Steroid effects on human endometrial glycoprotein biosynthesis.

@article{Lambadarios1976SteroidEO,
  title={Steroid effects on human endometrial glycoprotein biosynthesis.},
  author={Carol Lambadarios and Claudia Hastings and J A Abo-Darub and Ian D. Cooke},
  journal={Journal of reproduction and fertility},
  year={1976},
  volume={46 2},
  pages={
          383-94
        }
}
Human endometrium from the secretory phase of the menstrual cycle was incubated with 3H- and 14C-labelled glucosamine and [3H]leucine. Incorporation into secreted extracellular glycoprotein and accumulation of the label into the microsomal fraction were measured. When oestradiol or progesterone were added to the medium, medroxyprogesterone acetate (MPA), ethynodiol diacetate and chlormadinone acetate reduced incorporation of glucosamine and MPA reduced incorporation of leucine into glycoprotein… 

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References

SHOWING 1-10 OF 28 REFERENCES
Steroid hormone-responsive, isolated endometrial cells.
TLDR
Data lend further support to the suggestion that a primary action of estrogen in its target cell involves specific changes in the ionic and biochemical profile of the cytoplasm which may ultimately be communicated to the nucleus.
Metabolism of 17β-Estradiol and Estrone by Human Proliferative Endometrium and Myometrium1
TLDR
In vitro incubation of human endometrium and myometrium has demonstrated both tissues to transform 17β-estradiol to estrone, and it is suggested that this capacity is of sufficient magnitude to necessitate consideration of the possible association of hormonal action with chemical change.
Organ culture of human endometrium. Effect of ovarian steroids.
EFFECTS OF CERTAIN 19‐NOR STEROIDS UPON REPRODUCTIVE PROCESSES
TLDR
No significant differences in effect on ovulation indices or on steroid output were found at the various dosages or with the several estrogens employed, however breakthrough bleeding was less when the dose was doubled and side-effects were more frequently noted when estrogen was added.
Organ Culture of Human Endometrium: Effects of Progesterone
TLDR
The anticipated secretory differentiative alterations of the progesterone-stimulated explants took place irrespective of the cycle day of origin of the endometrium, and were associated with augmented alkaline phosphatase activity of the glandular cells.
Dating the endometrial biopsy.
Role for steroid hormones in the interaction of ribosomes with the endoplasmic membranes of rat liver.
Binding sites on intracellular membranes in rat fiver cells seem to be sex specific. Activation of isolated endoplasmic reticulum depends on oestradiol in the male, and on testosterone in the female.
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