Steroid effects on human endometrial glycoprotein biosynthesis.

  title={Steroid effects on human endometrial glycoprotein biosynthesis.},
  author={Carol Lambadarios and Claudia Hastings and J A Abo-Darub and Ian D. Cooke},
  journal={Journal of reproduction and fertility},
  volume={46 2},
Human endometrium from the secretory phase of the menstrual cycle was incubated with 3H- and 14C-labelled glucosamine and [3H]leucine. Incorporation into secreted extracellular glycoprotein and accumulation of the label into the microsomal fraction were measured. When oestradiol or progesterone were added to the medium, medroxyprogesterone acetate (MPA), ethynodiol diacetate and chlormadinone acetate reduced incorporation of glucosamine and MPA reduced incorporation of leucine into glycoprotein… 

Tables from this paper

Regulation of N-linked glycoprotein assembly in uteri by steroid hormones.
It appears, therefore, that estrogen priming induces the secretion of a few specific glycoproteins while generally enhancing the production of most tissue-associated glyCoproteins in ovariectomized mice.
Synthesis of a mucous glycoprotein in the human uterus.
Ultrastructure of human endometrial epithelium in monolayer culture with and without steroid hormones
Isolation of epithelial cells of endometrium in monolayer culture may provide a useful model system in which to study the specific effects of steroid hormones on cellular function and differentiation.
Glycoprotein Expression and Function in Embryo-Uterine Interactions
It appears that glycoprotein expression by the embryo and the uterus is quite dynamic, which is likely to have important consequences with regard to the cell-cell interactions that occur during implantation.
Evidence for the Existence of Human Uteroglobin
Implantation is characterized by the distinction of an area of the uterus adjacent to the blastocyst from other uterine areas as well as the secretion of proteolytic enzymes by the trophoblast, the production of which is under the influence of ovarian steroids.
The glycobiology of implantation.
  • D. Carson
  • Biology
    Frontiers in bioscience : a journal and virtual library
  • 2002
It is suggested that carbohydrate bearing molecules at embryonic and uterine cell surfaces play diverse roles during the implantation process that are similar to the roles suggested for these molecules in other biological contexts.
The biochemical pharmacology of mucus.
The pharmacology of agents which affect mucus and its production, and of drugs used in the treatment of mucus diseases, is largely unwritten. Classical texts, such as Goodman and Gilman (1975),


Steroid hormone-responsive, isolated endometrial cells.
Data lend further support to the suggestion that a primary action of estrogen in its target cell involves specific changes in the ionic and biochemical profile of the cytoplasm which may ultimately be communicated to the nucleus.
Metabolism of 17β-Estradiol and Estrone by Human Proliferative Endometrium and Myometrium1
In vitro incubation of human endometrium and myometrium has demonstrated both tissues to transform 17β-estradiol to estrone, and it is suggested that this capacity is of sufficient magnitude to necessitate consideration of the possible association of hormonal action with chemical change.
Organ culture of human endometrium. Effect of ovarian steroids.
No significant differences in effect on ovulation indices or on steroid output were found at the various dosages or with the several estrogens employed, however breakthrough bleeding was less when the dose was doubled and side-effects were more frequently noted when estrogen was added.
Organ Culture of Human Endometrium: Effects of Progesterone
The anticipated secretory differentiative alterations of the progesterone-stimulated explants took place irrespective of the cycle day of origin of the endometrium, and were associated with augmented alkaline phosphatase activity of the glandular cells.
Dating the endometrial biopsy.
Role for steroid hormones in the interaction of ribosomes with the endoplasmic membranes of rat liver.
Binding sites on intracellular membranes in rat fiver cells seem to be sex specific. Activation of isolated endoplasmic reticulum depends on oestradiol in the male, and on testosterone in the female.