Steroid derivatives for electrophilic affinity labelling of glucocorticoid binding sites: interaction with the glucocorticoid receptor and biological activity.

@article{Weisz1983SteroidDF,
  title={Steroid derivatives for electrophilic affinity labelling of glucocorticoid binding sites: interaction with the glucocorticoid receptor and biological activity.},
  author={Alessandro Weisz and R L Buzard and Dr. Siegfried Horn and M. P. Li and Lois V. Dunkerton and Francis S Markland},
  journal={Journal of steroid biochemistry},
  year={1983},
  volume={18 4},
  pages={
          375-82
        }
}
To investigate the possible use of electrophilic affinity labelling for the characterization of glucocorticoid receptors, different chemically reactive derivatives of deoxycorticosterone (deoxycorticosterone 21-mesylate and deoxycorticosterone 21-(1-imidazole) carboxylate), dexamethasone (dexamethasone 21-mesylate, dexamethasone 21-iodoacetate and dexamethasone 21-bromoacetate) and progesterone (21-chloro progesterone) were tested for their ability to bind irreversibly to the glucocorticoid… CONTINUE READING