Steroid biosynthesis in prokaryotes: identification of myxobacterial steroids and cloning of the first bacterial 2,3(S)‐oxidosqualene cyclase from the myxobacterium Stigmatella aurantiaca

@article{Bode2003SteroidBI,
  title={Steroid biosynthesis in prokaryotes: identification of myxobacterial steroids and cloning of the first bacterial 2,3(S)‐oxidosqualene cyclase from the myxobacterium Stigmatella aurantiaca},
  author={Helge B. Bode and Bernd Zeggel and Barbara Silakowski and Silke C Wenzel and Hans Prof Dr Reichenbach and Rolf M{\"u}ller},
  journal={Molecular Microbiology},
  year={2003},
  volume={47}
}
Steroids, such as cholesterol, are synthesized in almost all eukaryotic cells, which use these triterpenoid lipids to control the fluidity and flexibility of their cell membranes. Bacteria rarely synthesize such tetracyclic compounds but frequently replace them with a different class of triterpenoids, the pentacyclic hopanoids. The intriguing mechanisms involved in triterpene biosynthesis have attracted much attention, resulting in extensive studies of squalene‐hopene cyclase in bacteria and (S… 
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
Investigation of the biosynthesis with labelled precursors revealed acetate, butyrate and phenylalanine as building blocks for 1.
Biosynthesis of Structurally Diverse Triterpenes in Plants: the Role of Oxidosqualene Cyclases
TLDR
The role of OSCs in generating triterpene skeletal diversity in plants is highlighted, and some triterpenes are suggested to play specialized/secondary function as defence compounds.
Divergent evolution of oxidosqualene cyclases in plants.
TLDR
The phylogenetic analysis suggests that expansion of OSC members in higher plants has occurred mainly through tandem duplication followed by positive selection and diversifying evolution, and consolidated the previous suggestion that dicot triterpene synthases have been derived from an ancestral lanosterol synthase instead of directly from their cycloartenol synthases.
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