Steroid binding alterations in tissue compartments of the vagina of control and neonatally diethylstilbestrol-treated adult mice.

@article{Eiger1990SteroidBA,
  title={Steroid binding alterations in tissue compartments of the vagina of control and neonatally diethylstilbestrol-treated adult mice.},
  author={Steven M. Eiger and Kimberly Tracey Mills and Howard Alan Bern},
  journal={Journal of steroid biochemistry},
  year={1990},
  volume={35 5},
  pages={
          617-21
        }
}
Steroid binding in both the vaginal epithelium and the vaginal fibromuscular wall (FMW) was compared in control and neonatally estrogen-treated mice. Neonatal treatment with a low dose of the estrogen diethylstilbestrol (DES) had no significant effect on adult estrogen binding within the assayed vaginal compartments; however, this treatment caused a 2-fold increase in the level of cytosolic progestin binding in the vaginal FMW over that in vehicle-treated mice. This low neonatal dose did not… CONTINUE READING
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