Steroid and xenobiotic receptor mediates a novel vitamin K2 signaling pathway in osteoblastic cells

The nuclear receptor steroid and xenobiotic receptor (SXR) is a transcriptional regulator activated by various biological and xenobiotic substances. We have recently shown that SXR is expressed in bone and that this receptor is critical for bone metabolism, particularly in osteoblastic cells. Vitamin K2, one of the critical nutrients in bone metabolism, has… CONTINUE READING