Steroid Constituents from the Soft Coral Sinularia nanolobata.

@article{Ngoc2016SteroidCF,
  title={Steroid Constituents from the Soft Coral Sinularia nanolobata.},
  author={Ninh Thi Ngoc and Pham Thi Thu Huong and Nguyen Van Thanh and Nguyen Xuan Cuong and Nguyen Hoai Nam and Do Cong Thung and Phan Van Kiem and Ch{\^a}u Văn Minh},
  journal={Chemical \& pharmaceutical bulletin},
  year={2016},
  volume={64 9},
  pages={
          1417-9
        }
}
Six steroids (1-6), including the two new compounds 3β,4α-dihydroxyergosta-5,24(28)-diene (1) and 24(S),28-epoxyergost-5-ene-3β,4α-diol (2), were isolated from the methanol extract of the Vietnamese soft coral Sinularia nanolobata. Their structures were elucidated by spectroscopic methods including one and two dimensional (1D- and 2D)-NMR, Fourier transform ion cyclotron resonance (FT-ICR)-MS, and circular dichroism (CD). Compound 2 exhibited moderate cytotoxicity against the acute leukemia (HL… 
View on PubMed
jstage.jst.go.jp
19 Citations
Highly Influential Citations
2
Background Citations
4
Results Citations
2

Figures and Tables from this paper

19 Citations

Citation Type

Citation Type

Cytotoxic Steroids from the Vietnamese Soft Coral Sinularia leptoclados.
TLDR
Fifteen steroids, including two new compounds, leptosteroid (1) and 5,6β-epoxygorgosterol (2) were isolated and structurally elucidated from the Vietnamese soft coral Sinularia leptoclados and showed significant cytotoxic activity against a panel of eight human cancer cell lines.
Cytotoxic Steroids from the Vietnamese Soft Coral Sinularia conferta.
Twelve steroids, including five new compounds 1-5, were isolated and structurally elucidated from a methanol extract of the Vietnamese soft coral Sinularia conferta. Their cytotoxic effects against…
STRUCTURE ELUCIDATION OF FOUR STEROIDS FROM THE SOFT CORAL SINULARIA NANOLOBATA
Four steroids namely 3 β -hydroxyergosta-5,24(28)-diene-7-one ( 1 ), dissesterol ( 2 ), 16 α -hydroxysarcosterol ( 3 ), and sarcophytosterol ( 4 ) were isolated form the soft coral Sinularia…
Sesquiterpene constituents from the soft coral Sinularia nanolobata
TLDR
Using various chromatographic separations, four sesquiterpenes, including two new compounds, Nanolobatols A and B, were isolated from the Vietnamese soft coral Sinularia nanolobata, and their structures were determined on the basis of spectroscopic data and by comparison with the literature values.
Sterol constituents from a cultured octocoral Sinularia sandensis (Verseveldt 1977)
New cytotoxic ergostane-type sterols from the Chinese soft coral Sinularia sp.
Isolation of Sesquiterpenoids and Steroids from the Soft Coral Sinularia brassica and Determination of Their Absolute Configuration
TLDR
Two undescribed rearranged cadinane-type sesquiterpenoids, named sinulaketol A-B, together with one new chlorinated steroid and two known polyhydroxylated steroids were isolated from the soft coral Sinularia brassica by extensive spectroscopic analysis.
Uncommon terpenoids with anti-inflammatory activity from the Hainan soft coral Sinularia tumulosa.
Cytotoxic steroid derivatives from the Vietnamese soft coral Sinularia brassica
TLDR
The structure elucidation was confirmed by spectroscopic methods including 1D, 2D NMR and HR-ESI-MS and the cytotoxic activities of all the isolated compounds against three human cancer cell lines were evaluated using MTT-based colorimetric assays.
Cytotoxic Compounds from Alcyoniidae: An Overview of the Last 30 Years
TLDR
This review aims to provide an updated overview of the compounds isolated from Alcyoniidae and displaying potential cytotoxic activity, and found that (22S,24S)-24-methyl-22,25-epoxyfurost-5-ene-3β,20β-diol and cladieunicellin I exhibited stronger cytotoxicity than their respective positive control and that their mechanism of action has not yet been further investigated.
...
1
2
...

References

SHOWING 1-10 OF 20 REFERENCES
Steroid constituents from the soft coral Sinularia microspiculata
TLDR
A methanol extract of the soft coral Sinularia microspiculata revealed five sterols, including two new compounds, found to be 7-oxogorgosterol and 16α-hydroxysarcosterol, which showed weak cytotoxic effects against HL-60 cell lines.
A new 9,11-secosterol from the soft coral Sinularia granosa.
Polyoxygenated Sterols from the South China Sea Soft Coral Sinularia sp
TLDR
The structures, including relative configurations of the new compounds, were elucidated by detailed analysis of spectroscopic data (IR, UV, NMR, MS) and by comparison with related reported compounds.
Secosteroids and Norcembranoids from the Soft Coral Sinularia nanolobata
TLDR
The structures of these metabolites were elucidated on the basis of extensive spectroscopic analysis and the anti-HCMV activity of 1–4 and its cytotoxicity against selected cell lines were evaluated.
Steroid and cembranoids from the Dongsha atoll soft coral Lobophytum sarcophytoides
A New 5α,8α-Epidioxysterol from the Soft Coral Sinularia gaweli
TLDR
The cytotoxicity of sterols 1–3 towards various tumor cells is reported and the structure of sterol 1 was established by spectroscopic methods and by comparison of the spectral data with those of known analogues.
Steroids from the Soft Coral Sinularia crassa
TLDR
Steroids 1 and 4 showed cytotoxicity toward the selected human liver cancer cells and the absolute configurations for the sugar moieties of 2–5 were determined by HPLC analysis on the o-tolylthiocarbamates derived from the liberated sugar after acid hydrolysis.
Two new neoclerodane diterpenoids from Scutellaria barbata D. Don growing in Vietnam
TLDR
Various chromatographic separations of the aerial parts of Scutellaria barbata afforded two new neoclerodane diterpenoids, scutebatas S and T (1 and 2), along with scutebata D (3), which exhibited moderate cytotoxic activities against HL-60 (promyeloblast) human cancer cells.
Polyoxygenated 24,28-epoxyergosterols inhibiting the proliferation of glioma cells from sea anemone Anthopleura midori
Bioactive Ergost-5-ene-3β/,7α-diol Derivatives from Pseudobersama mossambicensis
TLDR
All three sterols showed selective activity towards DNA repair-deficient yeast mutants and the sterol 1 also showed cytotoxicity towards wild-type P-388 murine leukemia cells.
...
1
2
...