Steroid 5α-reductase 1 promotes 5α-androstane-3α,17β-diol synthesis in immature mouse testes by two pathways

@article{Mahendroo2004Steroid51,
  title={Steroid 5$\alpha$-reductase 1 promotes 5$\alpha$-androstane-3$\alpha$,17$\beta$-diol synthesis in immature mouse testes by two pathways},
  author={Mala Mahendroo and Jean D. Wilson and James A. Richardson and Richard J. Auchus},
  journal={Molecular and Cellular Endocrinology},
  year={2004},
  volume={222},
  pages={113-120}
}
Abstract 5α-Androstane-3α,17β-diol (androstanediol) is the predominant androgen in immature mouse testes, and studies were designed to investigate its pathway of synthesis, the steroid 5α-reductase isoenzyme involved in its formation, and whether testicular androstanediol is formed in embryonic mouse testes at the time of male phenotypic development. In 24–26-day-old immature testes, androstanediol is formed by two pathways; the predominant one involves testosterone → dihydrotestosterone… Expand
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The timing of androstanediol formation in the possum testis resembles the process in rodents rather than in the tammar wallaby and that any androStanediol in the circulation probably acts in target tissues via conversion to dihydrotestosterone. Expand
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  • R. Auchus
  • Medicine, Biology
  • Trends in Endocrinology & Metabolism
  • 2004
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TLDR
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TLDR
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