Steroid 21-hydroxylase mutations and 21-hydroxylase messenger ribonucleic acid expression in human adrenocortical tumors.

@article{Beuschlein1998Steroid2M,
  title={Steroid 21-hydroxylase mutations and 21-hydroxylase messenger ribonucleic acid expression in human adrenocortical tumors.},
  author={Felix Beuschlein and E. R. Schulze and Puig Mora and H P Gensheimer and Christiane Maser-Gluth and Bruno Allolio and Martin Reincke},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1998},
  volume={83 7},
  pages={2585-8}
}
Twenty-one hydroxylase (P450c21) is a key enzyme essential for normal zona glomerulosa and fasciculata function. Recently, 21-hydroxylase deficiency has been implicated in the pathogenesis of adrenocortical tumors. Therefore, we investigated the mutational spectrum of the CYP21B gene and the messenger RNA expression of P450c21 in six aldosterone-producing adenomas, seven cortisol-producing adenomas, two nonfunctional incidentally detected adenomas, and four adrenal carcinomas. DNA from… CONTINUE READING
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Molekularbiologie der zufällig diagnostizierten Nebennierenraumforderung

  • M Reincke, B. Allolio
  • Zentralbl Chir
  • 1997
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