Sterilizing activity of R207910 (TMC207)-containing regimens in the murine model of tuberculosis.

@article{Ibrahim2009SterilizingAO,
  title={Sterilizing activity of R207910 (TMC207)-containing regimens in the murine model of tuberculosis.},
  author={Murad A Ibrahim and Ch. Truffot-Pernot and Koen Andries and Vincent Jarlier and Nicolas Veziris},
  journal={American journal of respiratory and critical care medicine},
  year={2009},
  volume={180 6},
  pages={
          553-7
        }
}
RATIONALE The diarylquinoline R207910 (TMC207) has potent bactericidal activity in a murine model of tuberculosis (TB), but its sterilizing activity has not been determined. OBJECTIVES To evaluate the sterilizing activity of R207910-containing combinations in the murine model of TB. METHODS Swiss mice were intravenously inoculated with 6 log(10) of Mycobacterium tuberculosis strain H37Rv, treated with R207910-containing regimens, and followed for 3 months to determine relapse rates… CONTINUE READING
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