Sterilizing activities of novel combinations lacking first- and second-line drugs in a murine model of tuberculosis.

@article{Williams2012SterilizingAO,
  title={Sterilizing activities of novel combinations lacking first- and second-line drugs in a murine model of tuberculosis.},
  author={Kathy N. Williams and Austin Minkowski and Opokua Amoabeng and Charles A Peloquin and Dinesh Taylor and Koen Andries and Robert S Wallis and Khisimuzi E Mdluli and Eric Nuermberger},
  journal={Antimicrobial agents and chemotherapy},
  year={2012},
  volume={56 6},
  pages={3114-20}
}
Novel oral regimens composed of new drugs with potent activity against Mycobacterium tuberculosis and no cross-resistance with existing agents are needed to shorten and simplify treatment for both drug-susceptible and drug-resistant tuberculosis. As part of a continuing effort to evaluate novel drug combinations for treatment-shortening potential in a murine model, we performed two long-term, relapse-based experiments. In the first experiment, several 3- and 4-drug combinations containing new… CONTINUE READING

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Importance of confirming data on the in vivo efficacy of novel antibacterial drug regimens against various strains of Mycobacterium tuberculosis

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