Sterilization of pulmonary delivery for beclomethasone drug particles

  title={Sterilization of pulmonary delivery for beclomethasone drug particles},
  author={ジェンティレ,マルコ and デルウオーモ,マルコ and ドラガーニ,マリア・コンチェッタ},
Sterilization methods of the water-insoluble solid medicinal substances is described. The method provides a sterilized suitable drug substance for pulmonary administration. In particular, the method is used in industrial plants for the production of inhalation delivery sterile glucocorticoid formulation so as to avoid modification of the impurity profile of the grain size distribution and drug. The method a mixture of micronized glucocorticoid and purified water only, preferably carried out by… CONTINUE READING