Sterilization of gentamicin containing collagen/PLGA microparticle composites.

  title={Sterilization of gentamicin containing collagen/PLGA microparticle composites.},
  author={Wolfgang Friess and Monika Schlapp},
  journal={European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V},
  volume={63 2},
In order to achieve implants which provide sustained release of gentamicin, microparticles based on a 50/50 Resomer 503/Resomer 502H blend were combined with collagen in order to achieve their fixation and to utilize the favorable effect of collagen on wound healing. Ethylene oxide treatment as well as beta- and gamma-irradiation were tested for sterilization of the collagen/PLGA-microparticle composite. All methods resulted in a decrease of molecular weight and glass transition temperature of… CONTINUE READING


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